1376459-00-5Relevant academic research and scientific papers
Base induced cyclobutenone rearrangements and its application in the synthesis of aromatic amines
Han, Xiaodan,Fu, Jianping,Hu, Juwu,Xiong, Wei,Wang, Huibin,Wu, Lei
, (2019)
A series of fully substituted 2-pyridone 2 and functionalized α-pyrones 3 are synthesized starting from cyclobutenones 1 under a base-promoter in toluene at 80 °C. This rearrangement is complimentary to the previously reported ring expansion of cyclobutenones, providing a divergent synthesis of corresponding products from the same precursor 1. In addition, α-pyrones 3 has also been applied to the synthesis of aromatic amines 7 in good yields (64–83%) and in a highly regioselective manner via D-A reaction under mild conditions.
Synthesis of acridines and persubstituted phenols from cyclobutenones and active methylene ketones
Han, Xiao-Dan,Zhao, Yu-Long,Meng, Jia,Ren, Chuan-Qing,Liu, Qun
experimental part, p. 5173 - 5178 (2012/07/03)
A new benzannulation strategy that proceeds via a regiospecific [4 + 2] cycloaddition of readily available cyclobutenones and active methylene ketones has been developed. On the basis of this strategy, persubstituted phenols/anilines with up to six different functional groups on the benzene ring were synthesized in a single step. In addition, a series of acridine derivatives were prepared in excellent yield from persubstituted phenols/anilines.
