137649-68-4

Upstream product

• 7533-40-6 (S)-2-amino-4-methylpentan-1-ol 
• 501-53-1 benzyl chloroformate 
• 6216-61-1 (S)-(-)-N-(benzyloxycarbonyl)leucinol 
• 70853-26-8 N-carbobenzoxy-L-leucinal 

Downstream Products

• 142285-62-9 [(S)-1-((S)-1-{(4R,5R)-5-[(S)-1-((S)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyl]-2,2-dimethyl-[1,3]dioxolan-4-yl}-3-methyl-butylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester 
• 222848-18-2 ((S)-1-{(S)-1-[(S)-1-((4R,5R)-5-{(S)-1-[(S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-3-methyl-butyrylamino]-3-methyl-butyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-ethyl)-carbamic acid benzyl ester 
• 222848-38-6 (1-{1-[1-(5-{1-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-3-methyl-butyrylamino]-3-methyl-butyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-methyl-propyl)-carbamic acid benzyl ester 
• 222848-24-0 (1-{1-[1-(5-{1-[2-(2-benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-methyl-butyrylamino]-3-methyl-butyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-3-methyl-butyl)-carbamic acid benzyl ester 
• 222848-30-8 (1-{1-[1-(5-{1-[2-(2-benzyloxycarbonylamino-3-phenyl-propionylamino)-3-methyl-butyrylamino]-3-methyl-butyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-3-methyl-butylcarbamoyl]-2-methyl-propylcarbamoyl}-2-phenyl-ethyl)-carbamic acid benzyl ester 
• 142285-44-7 {1-[5-(1-benzyloxycarbonylamino-3-methyl-butyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-3-methyl-butyl}-carbamic acid benzyl ester 
• 137649-74-2 (4S,5R,4'S,5'R)-4,4'-Diisobutyl-[5,5']bioxazolidinyl-2,2'-dione 
• 100-51-6 benzyl alcohol 
• 137649-80-0 (4S,5R,4'S,5'R)-4,4'-Diisobutyl-3,3'-bis-((R)-3,3,3-trifluoro-2-methoxy-2-phenyl-propionyl)-[5,5']bioxazolidinyl-2,2'-dione 

Relevant academic research and scientific papers

Expedient solid-phase synthesis of both symmetric and asymmetric diol libraries targeting aspartic proteases

C2-symmetric diols have been shown to be highly potent against HIV-1 protease (PR). However, gaining access to these compounds has been hampered by the need of multistep solution-phase reactions which are often tedious and inefficient. In this Letter, we have disclosed a solid-phase strategy for rapid preparation of small molecule-based, symmetric and asymmetric diols as potential HIV-1 protease inhibitors. Upon biological screening, we found one of them, SYM-5, to be a potent and selective inhibitor (Ki = 400 nM) against HIV-1 protease.

Pinacol Homocoupling of (S)-2- Aldehydes by 2. Synthesis of C2-Symmetric (1S,2R,3R,4S)-1,4-Diamino 2,3-Diols

Six (S)-2- aldehydes 3a-f were homocoupled by 2 (1) to give C2-symmetric (1S,2R,3R,4S)-1,4-bis 2,3-diols 4a-f in good yield.High-yield conversions of the diols to biso