1376606-06-2Relevant academic research and scientific papers
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
Menendez, Christophe,Chollet, Aurélien,Rodriguez, Frédéric,Inard, Cyril,Pasca, Maria Rosalia,Lherbet, Christian,Baltas, Michel
, p. 275 - 283 (2012/07/30)
A series of triazoles have been prepared and evaluated as inhibitors of InhA as well as inhibitors of Mycobacterium tuberculosis H37R v. Several of these new compounds possess a good activity against InhA, particularly compounds 17 and 18 for which molecular docking has been performed. Concerning their activities against M. tuberculosis H 37RV strain, two of them, 3 and 12, were found to be good inhibitors with MIC values of 0.50 and 0.25 μg/mL, respectively. Particularly, compound 12 presenting the best MIC value of all compounds tested (0.6 μM) is totally inactive against InhA.
