1376606-07-3Relevant academic research and scientific papers
Facile synthesis of a luminescent copper(I) coordination polymer containing a flexible benzotriazole-based ligand: An effective catalyst for three-component azide-alkyne cycloaddition
Nu?ez-Dallos, Nelson,Mu?oz-Castro, Alvaro,Fuentealba, Mauricio,Pérez, Edwin G.,Hurtado, John J.
, (2019/09/18)
A straightforward method for the synthesis of a new luminescent copper(I) coordination polymer (CP) containing the ligand 1,3-bis(1H-benzotriazol-1-ylmethyl)benzene (L) through a self-assembly process with copper(I) iodide is reported. The CP was characte
Magnetically recyclable γ-Fe2O3-HAP nanoparticles for the cycloaddition reaction of alkynes, halides and azides in aqueous media
Kale, Sandip R.,Kahandal, Sandeep S.,Gawande, Manoj B.,Jayaram, Radha V.
, p. 8184 - 8192 (2013/09/02)
A simple and novel γ-Fe2O3 supported on hydroxyapatite (HAP) heterogeneous catalytic system is described that is useful in the synthesis of disubstituted 1,2,3-triazoles from terminal alkynes and in situ generated organic azide in aqueous media; this green methodology emerges as this new catalyst for the one-pot synthesis of 1,2,3-triazoles can be used in water without the addition of any reagent/base. The catalyst can be successfully recycled five times without significant loss of activity. It is important to note that 100% regioselectivity was observed for the cycloaddition reaction.
Chemical synthesis and biological evaluation of triazole derivatives as inhibitors of InhA and antituberculosis agents
Menendez, Christophe,Chollet, Aurélien,Rodriguez, Frédéric,Inard, Cyril,Pasca, Maria Rosalia,Lherbet, Christian,Baltas, Michel
, p. 275 - 283 (2012/07/30)
A series of triazoles have been prepared and evaluated as inhibitors of InhA as well as inhibitors of Mycobacterium tuberculosis H37R v. Several of these new compounds possess a good activity against InhA, particularly compounds 17 and 18 for which molecular docking has been performed. Concerning their activities against M. tuberculosis H 37RV strain, two of them, 3 and 12, were found to be good inhibitors with MIC values of 0.50 and 0.25 μg/mL, respectively. Particularly, compound 12 presenting the best MIC value of all compounds tested (0.6 μM) is totally inactive against InhA.
