1376642-16-8Relevant academic research and scientific papers
Synthesis and biological evaluation of novel oxazolo[5,4-d]pyrimidines as potent vegfr-2 inhibitors
Deng, Ya-Hui,Xu, Dan,Su, Ye-Xiang,Cheng, Yi-Juan,Yang, Yan-Li,Wang, Xiu-Yun,Zhang, Juan,You, Qi-Dong,Sun, Li-Ping
, p. 528 - 537 (2015/04/27)
Tumor angiogenesis is mediated by vascular endothelial growth factor receptor (VEGFR) and other protein kinases. Inhibition of these kinases presents an attractive approach for developing anticancer therapeutics. In this work, a series of 2,5,7-trisubstit
Facile synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines via copper-catalyzed intramolecular C-O bond formation
Xu, Dan,Sun, Li-Ping,You, Qi-Dong
, p. 4248 - 4251 (2012/07/14)
A novel and convenient synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines was presented. The key step involved an intramolecular C-O cross-coupling of the ortho-halopyrimidine amide via a copper (I)-mediated cyclization reaction, which provided t
