1376702-38-3Relevant academic research and scientific papers
Organocatalytic asymmetric oxy-Michael addition to a γ-hydroxy- α,β-unsaturated thioester via hemiacetal intermediates
Okamura, Takaaki,Asano, Keisuke,Matsubara, Seijiro
supporting information; experimental part, p. 5076 - 5078 (2012/07/02)
We report an asymmetric oxy-Michael addition to a γ-hydroxy-α, β-unsaturated thioester via hemiacetal intermediates in the presence of Cinchona-alkaloid-thiourea-based bifunctional organocatalysts. This method provides a novel enantioselective route to β-hydroxy carboxyl compounds, which in turn can be used to synthesize valuable chiral building blocks.
