1376706-27-2Relevant academic research and scientific papers
Enantioselective direct aldol reaction of α-keto esters catalyzed by (Sa)-binam-d-prolinamide under quasi solvent-free conditions
Viozquez, Santiago F.,Banon-Caballero, Abraham,Guillena, Gabriela,Najera, Carmen,Gomez-Bengoa, Enrique
, p. 4029 - 4035 (2012)
(Sa)-Binam-d-prolinamide (20 mol%), instead of (S a)-binam-l-prolinamide, in combination with chloroacetic acid (100 mol%) is an efficient organocatalyst for the direct aldol reaction between α-keto esters as electrophiles and alkyl and α-functionalised ketones, under quasi solvent-free conditions, providing access to highly functionalised chiral quaternary γ-keto α-hydroxyesters with up to 92% ee.
