1376707-75-3Relevant academic research and scientific papers
Useful, regioflexible methods for functionalization of 1-phenylpyrrole derivatives
Faigl, Ferenc,Mátrav?lgyi, Béla,Deák, Szilvia,Holczbauer, Tamás,Czugler, Mátyás,Balázs, László,Hermecz, István
, p. 4259 - 4266 (2012)
Highly regioselective mono-, di- and tribrominations of 1-[2-(trifluoromethyl)phenyl]-1H-pyrrole and several derivatives were accomplished with N-bromosuccinimide under mild conditions. Combined applications of these brominations with organometallic (e.g., bromine/lithium exchange or metalation) reactions provided a novel regioflexible route to new multifunctionalised 1-phenylpyrrole derivatives. The structures of the new products were determined by spectroscopic methods and confirmed in three cases with single crystal X-ray diffraction measurements.
