1376769-58-2

Basic information

• Product Name: C₁₈H₂₁BN₄O₃
• CAS NO: 1376769-58-2
• Molecular Weight: 352.201
• Mol File: 1376769-58-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₁BN₄O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₁BN₄O₃(1376769-58-2)
• EPA Substance Registry System: C₁₈H₂₁BN₄O₃(1376769-58-2)

Safety Data

• Hazardous Substances Data: 1376769-58-2(Hazardous Substances Data)

Upstream product

• 269410-08-4 pyrazole-4-boronic acid pinacol ester 
• 1201-68-9 3-chloromethyl-5-phenyl-1,2,4-oxadiazole 

Relevant articles and documents

Synthesis and SAR studies of imidazo-[1,2-a]-pyrazine Aurora kinase inhibitors with improved off-target kinase selectivity

The structure-activity relationships of new Aurora A/B kinase inhibitors derived from the previously identified kinase inhibitor 12 are described. Introduction of acetic acid amides onto the pyrazole of compound 12 was postulated to influence Aurora A/B selectivity and improve the profile against off-target kinases. The SAR of the acetic acid amides was explored and the effect of substitution on enzyme inhibition as well as mechanism-based cell activity was studied. Additionally, several of the more potent inhibitors were screened for their off-target kinase selectivity.