1376827-47-2

Upstream product

• 1376827-52-9 5'-O-tert-butyldimethylsilyl-3'-O-triethylsilyl-2'-deoxyguanosine 
• 612-25-9 2-Nitrobenzyl alcohol 
• 961-07-9 2'-Deoxyguanosine 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 51549-33-8 2’-deoxy-5’-O-tert-butyldimethylsilylguanosine 

Downstream Products

• 1376827-51-8 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2-chloroethyl)-5''-O-dimethoxytrityl-3'-O-(2-cyanoethyl-N,N-diisopropylphosphoramidite)-2'-deoxyguanosine 
• 1376827-54-1 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2-chloroethyl)-5'-O-dimethoxytrityl-2'-deoxyguanosine 
• 1376827-50-7 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2-chloroethyl)-2'-deoxyguanosine 
• 1376827-49-4 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2-chloroethyl)-5'-O-tert-butyldimethylsilyl-3'-O-triethylsilyl-2'-deoxyguanosine 
• 1376827-48-3 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2-hydroxyethyl)-5'-O-tert-butyldimethylsilyl-3'-O-triethylsilyl-2'-deoxyguanosine 
• 1376827-53-0 N⁽²⁾-(2-nitrobenzylcarbonyl)-O⁽⁶⁾-(2,4,6-triisopropylphenylsulfonyl)-5'-O-tert-butyldimethylsilyl-3'-O-triethylsilyl-2'-deoxyguanosine 

Relevant academic research and scientific papers

Synthesis of DNA interstrand cross-links using a photocaged nucleobase

The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge between N1 of deoxyguanosine and N3 of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU (see scheme, NBOC=ortho- nitrobenzyloxycarbonyl). Copyright