137693-13-1Relevant academic research and scientific papers
First total synthesis of A2 isoprostane
Zanoni, Giuseppe,Porta, Alessio,Vidari, Giovanni
, p. 4346 - 4351 (2002)
A stereoselective Julia-Lythgoe olefination has allowed the first total synthesis of A2 isoprostane (1), a recently discovered member of the growing isoprostane family. This elusive compound opens up numerous new avenues for the molecular biology of cyclopentenone prostaglandins, which are endowed of intriguing biological effects such as antitumor, antiinflammatory, and antiviral activities.
Total Synthesis of Prostaglandin A2 involving the Reaction of a Heterocuprate Reagent with an Allyl Epoxide
Chapleo, Christopher B.,Finch, Mark A. W.,Lee, Thomas V.,Roberts, Stanley M.,Newton, Roger F.
, p. 2084 - 2087 (2007/10/02)
A new route to prostaglandin A2 (18) involves as the key step the SN' anti reaction of the allyl epoxide (12) and the cuprate reagent (9).
