1377151-84-2

Upstream product

• 753004-76-1 [5-(tert-butyl-dimethyl-silanyloxymethyl)-furan-2-yl]-methanol 
• 155108-06-8 5-(((tert-butyldimethylsilyl)oxy)methyl)furan-2-carbaldehyde 
• 164145-69-1 1(S)-[(2R)-1,4-dioxaspiro[4.5]decanyl]-3-buten-1-ol 
• 121389-55-7 tert-butyl(furan-2-ylmethoxy)dimethylsilane 
• 125803-73-8 (2R,3S)-1-((tert-butyldiphenylsilyl)oxy)hex-5-ene-2,3-diol 
• 79364-36-6 (2R,3S)-hex-5-ene-1,2,3-triol 
• 1377151-83-1 C₂₅H₃₄O₄Si 
• 1377151-82-0 6-(((tert-butyldimethylsilyl)oxy)methyl)-6-hydroxy-2H-pyran-3(6H)-one 
• 1377151-81-9 C₂₅H₃₇NO₄Si 
• 1251854-62-2 C₂₅H₃₄O₃Si 

Downstream Products

• 1377151-80-8 C₃₇H₅₃NO₆Si₂ 

Relevant academic research and scientific papers

Synthesis of the revised structure of acortatarin A

A novel Maillard-type condensation between a primary amine derived from D-mannitol and a dihydropyranone, was used as a key step to access the unusual morpholine-spiroketal acortatarin A. The synthetic approach also enabled access to a C-2 analogue of acortatarin A, and can be used for the synthesis of related 2-formylpyrrole natural products.

A convergent synthesis of the 2-formylpyrrole spiroketal natural product acortatarin A

A concise and flexible synthesis of the morpholine-spiroketal natural product acortatarin A, isolated from the traditional Chinese medicine Acorus tatarinowii, is reported. The key step involves a Maillard-type condensation of an amine derived from d-mannitol with a dihydropyranone. The approach also enables access to analogues of acortatarin A for biological evaluation and can be applied to the synthesis of related 2-formylpyrrole natural products. Georg Thieme Verlag Stuttgart . New York.