137718-66-2Relevant academic research and scientific papers
2β-Substituted Analogues of Cocaine. Synthesis and Inhibition of Binding to the Cocaine Receptor
Lewin, Anita H.,Gao, Yigong,Abraham, Philip,Boja, John W.,Kuhar, Michael J.,Carroll, F. Ivy
, p. 135 - 140 (2007/10/02)
The potencies of a series of 2β-substituted cocaine analogues to displace -3β-(p-fluorophenyl)tropane-2β-carboxylic acid methyl ester binding in rat striatal membranes demonstrate the requirement for a 2β-substituent with two hydrogen-bond acceptors.The insensitivity of the ester moiety to steric and electronic factors suggests its modification to provide site-specific irreversible ligands.
