1377239-83-2 Usage
Description
PBTZ169 is an antibiotic with antimycobacterial activity. It is an irreversible inhibitor of DprE1, an essential enzyme for cell wall synthesis in mycobacteria. PBTZ169 is active against M. tuberculosis in vitro (MIC = ≤0.19 ng/ml) without inducing cytotoxicity in Vero cells when used at concentrations up to 125 μM. It reduces the bacterial burden in the lung and spleen in a mouse model of chronic tuberculosis when administered at a dose of 50 mg/kg per day.
Uses
PBTZ169 is a potent irreversible inhibitor of decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1), and display nanomolar bactericidal activity against Mycobacterium tuberculosis in vitro.
Check Digit Verification of cas no
The CAS Registry Mumber 1377239-83-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,7,2,3 and 9 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1377239-83:
(9*1)+(8*3)+(7*7)+(6*7)+(5*2)+(4*3)+(3*9)+(2*8)+(1*3)=192
192 % 10 = 2
So 1377239-83-2 is a valid CAS Registry Number.
1377239-83-2Relevant articles and documents
Macozinone: Revised synthesis and crystal structure of a promising new drug for treating drug-sensitive and drug-resistant tuberculosis
Zhang, Gang,Aldrich, Courtney C.
, p. 1031 - 1035 (2019)
Mycobacterium tuberculosis (Mtb), the principal etiological agent of tuberculosis (TB), infects over one-quarter of humanity and is now the leading cause of infectious disease mortality by a single pathogen. Macozinone {2-[4-(cyclohexylmethyl)piperazin-1-
2-PIPERAZIN-1-YL-4H-1,3-BENZOTHIAZIN-4-ONE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF MAMMALIAN INFECTIONS
-
Paragraph 0126-0134, (2013/09/26)
The present invention relates to new 2-piperazin-1-yl-4H-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections caused by bacteria, especially diseases like tuberculosis (TB), Buruli ulcer and leprosy that result from i
