1377454-70-0Relevant articles and documents
Discovery of EBI-907: A highly potent and orally active B-RafV600Einhibitor for the treatment of melanoma and associated cancers
Lu, Biao,Cao, Hu,Cao, Jingsong,Huang, Song,Hu, Qiyue,Liu, Dong,Shen, Ru,Shen, Xiaodong,Tao, Weikang,Wan, Hong,Wang, Dan,Yan, Yinfa,Yang, Liuqing,Zhang, Jiayin,Zhang, Lei,Zhang, Lianshan,Zhang, Minsheng
, p. 819 - 823 (2016/05/24)
A novel series of pyrazolo[3,4-c]isoquinoline derivatives was discovered as B-RafV600Einhibitors through scaffold hopping based on a literature lead PLX4720. Further SAR exploration and optimization led to the discovery of potent B-RafV600
