1377495-57-2Relevant academic research and scientific papers
Synthesis of the AB-DE ring system present in the alstoscholarine alkaloids
Polindara-Garcia, Luis A.,Miranda, Luis D.
experimental part, p. 1051 - 1056 (2012/05/05)
A practical protocol is presented for the construction of the AB-DE rings present in (19,20)-(E)- and (19,20)-(Z)-alstoscholarine alkaloids from the commercially available glutamic acid 5-methyl ester, employing only a six-step synthetic sequence. The main features include the synthesis of the alkynylindolizinone core and the use of Sonogashira cross-coupling and base-mediated cyclization to afford a 2-substituted indole without the use of protecting groups. Georg Thieme Verlag Stuttgart · New York.
