137754-99-5

Basic information

• Product Name: 3-amino-9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one
• Synonyms: 3-amino-9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one
• CAS NO: 137754-99-5
• Molecular Weight: 329.761
• Mol File: 137754-99-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-amino-9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one(137754-99-5)
• EPA Substance Registry System: 3-amino-9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one(137754-99-5)

Safety Data

• Hazardous Substances Data: 137754-99-5(Hazardous Substances Data)

Upstream product

• 126149-67-5 9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-[1,4]diazepino[6,7,1-hi]indole-3,4-dione 3-oxime 
• 126149-66-4 9-chloro-1-(2-fluoro-phenyl)-6,7-dihydro-3H-[1,4]diazepino[6,7,1-hi]indol-4-one 
• 126149-64-2 5-chloro-7-(2-fluorobenzoyl)indoline 
• 394-47-8 2-fluorobenzonitrile 
• 25658-80-4 5-chloro-2,3-dihydroindole 

Relevant articles and documents

Synthesis and structure-activity relationships of 4-oxo-1-phenyl- 3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: Novel PDE4 inhibitors

A novel series of benzodiazepine derivatives have been discovered as inhibitors of PDE4 enzymes. We have found that our compounds are selective versus other PDE enzymes, and that the activity can be modulated by specific structural modifications. One compound exhibited a strong eosinophilic infiltration inhibiting action on sensitized Brown-Norway rats (compound 9, 5.1 mg/kg p.o.), moreover this compound is not emetic at 3 mg/kg i.v.