1377585-52-8

Upstream product

• 66-77-3 1-naphthaldehyde 
• 4381-25-3 S-methyl-S-phenylsulfoximine 
• 67087-35-8 N-chloro-S-methyl-S-phenyl sulfoximine 
• 90-12-0 1-Methylnaphthalene 
• 201230-82-2 carbon monoxide 
• 90-14-2 1-Iodonaphthalene 
• 86-55-5 1-naphthalenecarboxylic acid 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 100-68-5 methyl-phenyl-thioether 

Downstream Products

• 1377585-22-2 N-[2-acetoxy-α-naptholoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-24-4 C₂₃H₂₁NO₄S 
• 1616088-33-5 N-[2-(3-ethoxy-3-oxopropyl)-α-naphtholoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-34-6 N-[2-(3-methoxy-3-oxopropyl)-α-naphtholoyl]-S-methyl-S-phenylsulfoximine 
• 1426922-43-1 N-[2-(4'-methylbenzenesulfonamido)-α-naptholoyl]-S-methyl-S-phenylsulfoximine 

Relevant academic research and scientific papers

Palladium nanoparticles catalyzed aroylation of: NH -sulfoximines with aryl iodides

A novel approach towards aroylation of NH-sulfoximines using Pd nanoparticles stabilized by a binaphthyl backbone (Pd-BNP) has been developed. This synthetic protocol involves the Pd-BNP promoted carbon monoxide insertion of aryl iodides to form an aroyl intermediate which further reacts with NH-sulfoximines to form N-aroyl sulfoximine derivatives in good to excellent yields. The Pd-BNP catalyst was recovered and reused up to six times.

Microwave-Accelerated N-Acylation of Sulfoximines with Aldehydes under Catalyst-Free Conditions

An efficient catalyst-free radical cross-coupling reaction between aromatic aldehydes and sulfoximines was developed. The reaction took place in the presence of N-bromosuccinimide as the radical initiator under microwave irradiation to afford the corresponding acylated sulfoximines in moderate to excellent yields (27 examples). This protocol proved to be rapid, easy to handle, and applicable to a broad scope of substrates.

Sulfoximinocarbonylation of aryl halides using heterogeneous Pd/C catalyst

A three component protocol has been developed for the synthesis of N-aroyl sulfoximines by the carbonylation of aryl halides followed by nucleophilic attack of NH-sulfoximines. This reaction tolerates a range of aryl iodides and sulfoximines to provide th

Iron-Catalyzed One-Pot N-Aroylation of NH-Sulfoximines with Methylarenes through Benzylic C-H Bond Oxidation

An efficient catalytic method has been developed for the synthesis of N-aroylated sulfoximines from readily available toluenes (methylarenes) as source of the aroyl coupling partner and NH-sulfoximines, employing an environmentally benign iron catalyst. T

TBAI/TBHP catalyzed direct N-acylation of sulfoximines with aldehydes

A direct N-acylation of NH-sulfoximines and aldehydes has been developed under metal-free TBAI/TBHP oxidation system, affording N-acylsulfoximines in moderate to good yields.

Sulfoximine-directed ruthenium-catalyzed ortho -C-H Alkenylation of (Hetero)Arenes: Synthesis of EP3 receptor antagonist analogue

The reusable sulfoximine directing-group-assisted Ru(II)-catalyzed chemo- and regioselective ortho-C-H alkenylation of arenes and heteroarenes with acrylates and α,β-unsaturated ketones/vinyl sulfone is shown. The N-aroyl sulfoximine undergoes annulation with diphenylacetylene, delivering isoquinolinones and methyl phenyl sulfoxide. The present protocol is successfully employed for the synthesis of the EP3 receptor antagonist analogue.

The copper-catalyzed oxidative N-acylation of sulfoximines

An oxidative cross-coupling reaction between aldehydes and sulfoximines involving dual C-H/N-H functionalization has been developed. This reaction process is facilitated by a simple copper catalyst (1 mol% loading) and tert-butyl hydroperoxide (TBHP) as the oxidant and proceeds under mild reaction conditions to afford a series of valuable N-acylated sulfoximine derivatives in excellent yields. Copyright

Sulfoximines: A reusable directing group for chemo-and regioselective ortho C-H oxidation of arenes

Sulfoximines direct: A new protocol for the chemo-and regioselective ortho C-H acetoxylation of arenes in N-benzoylated sulfoximines is reported. The sulfoximine directing group is easily detached from the C-H oxidation product through acid-promoted hydrolysis, isolated, and reused (see scheme). The meta-substituted phenols are synthesized following this strategy and the stereointegrity of the sulfoximine is preserved in this transformation. C(sp3)-H acetoxylation of the methyl group is also demonstrated.