137762-80-2Relevant academic research and scientific papers
One-pot oxidative hydrolysis-oxidative cleavage of 7-borylindoles enables access to: O -amidophenols and 4-acylbenzoxazoles
Anderson, Kirsty,Eastabrook, Andrew S.,Sperry, Jonathan
supporting information, p. 3559 - 3562 (2020/04/09)
7-Borylindoles undergo a one-pot oxidative-hydrolysis of the arylboronate and oxidative cleavage of the indole C2-C3 double bond to afford o-amidophenol derivatives. Subsequent cyclisation delivers benzoxazoles bearing an acyl group at C4, a substitution pattern common to fungal-derived benzoxazole alkaloids. Using 7-borylindoles as substrates to access functionalised o-amidophenols circumvents the difficult preparation of these compounds from arenes, streamlining access to substituted 4-acylbenzoxazoles in the process.
2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines
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, (2008/06/13)
2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula STR1 in which R1 and R5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, R2 represents nitro or cyano, or R1 and R2 together form a lactone ring of the formula STR2 R3 represents a radical of the formula STR3 R4 -R7 are defined hereinafter and physiologically acceptable salts thereof.
