137764-83-1Relevant academic research and scientific papers
SINTESIS ENANTIOSELECTIVA DEL FRAGMENTO C9-C13 DE LA ERITROMICINA B
Dominguez, E.,Carretero, J. C.
, p. 397 - 402 (2007/10/02)
A stereocontrolled synthesis of the enantiomerically pure C9-C13 fragment of erythromycin B is described.The process takes place in 15 steps from (R)-phenylsulfonyl p-tolylsulfinyl methane and butyraldehyde (16percent overall yield).The key steps, corresponding to the formation of the chiral centers, are based on the iterative synthesis of γ-hydroxyvinylsulfones and further syn-stereoselective addition of MeLi to their protected derivatives.
