137778-20-2

Basic information

• Product Name: 3-BroMo-2-Methylpyridine-6-carboxylic acid
• Synonyms: 3-BroMo-2-Methylpyridine-6-carboxylic acid;5-Bromo-6-methyl-pyridine-2-carboxylic acid
• CAS NO: 137778-20-2
• Molecular Formula: C₇H₆BrNO₂
• Molecular Weight: 216.03204
• Mol File: 137778-20-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 313.7±42.0 °C(Predicted)
• Appearance: /
• Density: 1.692±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.48±0.10(Predicted)
• CAS DataBase Reference: 3-BroMo-2-Methylpyridine-6-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BroMo-2-Methylpyridine-6-carboxylic acid(137778-20-2)
• EPA Substance Registry System: 3-BroMo-2-Methylpyridine-6-carboxylic acid(137778-20-2)

Safety Data

• Hazardous Substances Data: 137778-20-2(Hazardous Substances Data)

Usage

General Description

3-Bromo-2-Methylpyridine-6-carboxylic acid is a brominated compound characterized by its pyridine ring (a six-membered aromatic heterocycle) and a carboxylic acid group. With the presence of bromine, it is related to halogenated compounds well-known for their reactivity and versatility for further modification. The methyl group and carboxylic acid group attached to the pyridine ring make this chemical versatile and fitting for the field of pharmaceuticals and organic synthesis. Its specific properties, such as reactivity, polarity, and acidity, are steered mainly by these functional groups and the aromatic pyridine ring. Although we can't find direct use or particular products relating to this compound, it's clear that it could hold potential as a building block in complex synthesis processes.

Upstream product

• 1122090-67-8 3-bromo-2-methyl-6-vinylpyridine 
• 1173897-86-3 5-bromo-6-methylpyridine-2-carbonitrile 
• 137778-11-1 (5-bromo-6-methylpyridin-2-yl)methanol 
• 87180-69-6 3‐bromo‐2,6‐dimethylpyridine‐1‐oxide 
• 137778-18-8 5-bromo-6-methyl-pyridine-2-carbaldehyde 

Downstream Products

• 1122090-71-4 ethyl 5-bromo-6-methylpyridine-2-carboxylate 

Relevant articles and documents

Novel S1P1 receptor agonists - Part 3: From thiophenes to pyridines

In preceding communications we summarized our medicinal chemistry efforts leading to the identification of potent, selective, and orally active S1P 1 agonists such as the thiophene derivative 1. As a continuation of these efforts, we replaced the thiophene in 1 by a 2-, 3-, or 4-pyridine and obtained less lipophilic, potent, and selective S1P1 agonists (e.g., 2) efficiently reducing blood lymphocyte count in the rat. Structural features influencing the compounds' receptor affinity profile and pharmacokinetics are discussed. In addition, the ability to penetrate brain tissue has been studied for several compounds. As a typical example for these pyridine based S1P 1 agonists, compound 53 showed EC50 values of 0.6 and 352 nM for the S1P1 and S1P3 receptor, respectively, displayed favorable PK properties, and penetrated well into brain tissue. In the rat, compound 53 maximally reduced the blood lymphocyte count for at least 24 h after oral dosing of 3 mg/kg.

THE REARRANGEMENT OF 3-CHLORO- AND 3-BROMO-2,6-DIMETHYLPYRIDINE N-OXIDE UNDER THE ACTION OF ACETIC ANHYDRIDE

The rearrangement of 3-chloro and 3-bromo-2,6-dimethylpyridine N oxides under the influence of acetic anhydride was investigated.The rearrangement products: 3-halo-2-methyyl-6-pyridylmethanol and 3-halo-2,6-dimethyl-5-hydroxypyridine acetates were separated and hydrolyzed to corresponding alcohols. 3-Halo-2-methyl-6-pyridylmethanols were oxidized to aldehydes and carboxylic acids.Structures of pyridylmethanols and hydroxy derivatives have been determined by IR spectra analysis or by chemical methods.