137786-87-9Relevant academic research and scientific papers
Method for preventing and for treating autoimmune disease
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, (2008/06/13)
A method for preventing or treating autoimmune diseases (excluding type I diabetes) by administering an insulin resistance improving substance as an active ingredient.
Use of thiazolidinediones to ameliorate the adverse consequences of myocardial ischemia on myocardial function and metabolism
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, (2008/06/13)
The present invention provides methods and compositions for (a) enhancing resistance to myocardial ischemia associated dysfunction, including contraction (systolic), relaxation (diastolic) and metabolic dysfunction, comprising the step of administering to a human determined to be susceptible to myocardial ischemia an effective amount of an insulin sensitizer; and (b) reducing hypertension comprising the step of administering to a hypertensive human determined to have normal insulin sensitivity, an effective amount of an insulin sensitizer. In a particular embodiment, the sensitizer comprises a thiazolidinedione compound, such as triglitazone.
Treatment and prophylaxis of pancreatitis
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, (2008/06/13)
Insulin sensitizers, especially thiazolidinedione compounds, such as troglitazone, are useful for the treatment and prevention of pancreatitis.
Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use
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, (2008/06/13)
Thiazolidine derivatives of formula (I): STR1 (in which: R1, R2, R4, R5 are each hydrogen or alkyl; and R3 is hydrogen, aliphatic acyl, alkoxy-carbonyl, or arylcarbonyl and pharmaceutically acceptable salts thereof are anti-hypertensive agents and are useful in the treatment of obesity-related hypertension.
