137787-62-3Relevant academic research and scientific papers
Total Synthesis of Novel Xanthone Antibiotics (+/-)-Cervinomycins A1 and A2
Mehta, Goverdhan,Shah, Shailesh R.,Venkateswarlu, Yenamandra
, p. 11729 - 11742 (2007/10/02)
A total synthesis of novel heptacyclic antibiotics cervinomycin A1 1 and A2 2 following a convergent approach is reported.The cornerstone of our strategy was the construction of the central ring D through photochemical electrocyclization.The oxazolo-isoquinoline fragment (ABC rings) 7 and the xanthone fragment (EFG rings) 8 were assembled through relatively straightforward synthetic protocols and coupled through a Wittig reaction to give 6 and set up the key photocyclization.Our successful approach to 1 and 2 can be readily adapted to the synthesis of analogues of these interesting antibiotics.
Total Synthesis of Cervinomycin A1-trimethyl Ether and Cervinomycin A2-methyl Ether
Mehta, Goverdhan,Shah, Shailesh R.
, p. 5195 - 5198 (2007/10/02)
The heptacyclic framework of cervinomycin antibiotics has been constructed through a C+EFG -> CEFG -> CDEFG -> ABCDEFG approach in which the photochemical generation of ring D was a key step.Key words: Xanthone antibiotics, Photocyclisation, Tetrahydrooxazolobenzisoquinolone formation.
