137789-54-9

Basic information

• Product Name: Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)-
• CAS NO: 137789-54-9
• Molecular Formula: C16H22NO6P
• Molecular Weight: 355.328
• Mol File: 137789-54-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)-(137789-54-9)
• EPA Substance Registry System: Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)-(137789-54-9)

Safety Data

• Hazardous Substances Data: 137789-54-9(Hazardous Substances Data)

Usage

General Description

Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)- is a chemical compound that is used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is an ester of phosphonic acid, and has a molecular structure containing a phenylmethyl group and an oxazolidinyl ring. Phosphonic acid, [2-oxo-2-[2-oxo-4-(phenylmethyl)-3-oxazolidinyl]ethyl]-, diethyl ester, (S)- is typically used in organic synthesis and catalysis, as well as in the production of specialty chemicals. It has the potential to exhibit biological activity and may be used as a building block in the development of new drugs and agrochemicals.

Upstream product

• 110905-24-3 (4R)-3-(bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 129549-13-9 4S-3-(2-bromoacetyl)-4-(phenylmethyl)-2-oxazolidinone 
• 122-52-1 triethyl phosphite 

Downstream Products

• 769169-30-4 (4R)-4-Benzyl-3-[(2E)-5,5,5-trifluoropent-2-enoyl]1,3-oxazolidin-2-one 
• 1214247-60-5 C₂₃H₃₀N₂O₆ 
• 334009-77-7 4(S)-Benzyl-3-[4-(2-methyl-[1,3]dioxolan-2-yl)-butyryl]-oxazolidin-2-one 
• 1353545-67-1 C₁₈H₂₂INO₃ 
• 143761-23-3 (+)-4S-3-[1'-oxo-6'-(benzyloxy)hexyl]-4-benzyl-2-oxazolidinone 
• 136159-65-4 (S)-4-benzyl-3-(3-phenylpropanoyl)oxazolidin-2-one 
• 133812-18-7 (S)-4-benzyl-3-(6-(benzyloxy)hex-2-enoyl)oxazolidin-2-one 
• 1353545-68-2 C₂₂H₂₆N₂O₅ 
• 136187-43-4 (4S)-3-(3-cyclohexyl-1-oxopropyl)-4-phenylmethyl-2-oxazolidinone 
• 923949-15-9 (4S)-4-benzyl-3-[(2E)-3-(5-chloropyridin-2-yl)prop-2-enoyl]-1,3-oxazolidin-2-one 

Relevant articles and documents

Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof

Compounds of Formula (I), are provided where T is CHO, CON, or C(OH)R1R2; R1 and R2 are hydrogen, optionally substituted lower alkyl, CF3, optionally substituted alkenyl, or optionally substituted alkynyl; R3 is hydrogen or optionally substituted lower alkyl; R4 is (CF3)nalkyl, (CF3)n(substitutedalkyl), (CF3)nalkylphenyl, (CF3)nalkyl(substitutedphenyl), or (F)ncycloalkyl; n=1-3; R5 is hydrogen, halogen, CF3, diene fused to Y when Y═C, or substituted diene fused to Y when Y═C; W, Y and Z are C, CR6 or N where at least one of W, Y or Z are C; R6 is hydrogen, halogen, or optionally substituted lower alkyl; X is O, S, SO2, or NR7; R7 is hydrogen, optionally substituted lower alkyl, optionally substituted benzyl, or optionally substituted phenyl; and R8 is lower alkyl, CF3, or optionally substituted phenyl. Methods of preparing and using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's Disease and Down's syndrome are also described.