1377966-46-5

Upstream product

• 119-67-5 o-carboxybenzaldehyde 
• 1377966-42-1 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-4-nitro-1-oxo-1,2-dihydroisoquinoline 
• 1377966-41-0 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-1-oxo-1,2-dihydroisoquinoline 
• 1377966-40-9 2-(3'-chloropropyl)-6,7-dimethoxy-3-(2'-methoxycarbonylphenyl)-1-oxo-1,2,3,4-tetrahydroisoquinoline 
• 1377966-35-2 methyl 2-[(3-chloropropylimino)methyl]benzoate 

Relevant academic research and scientific papers

Dibenzo[c,h][1,5]naphthyridinediones as topoisomerase i inhibitors: Design, synthesis, and biological evaluation

Dibenzo[c,h][1,5]naphthyridinediones were prepared via a novel synthetic pathway. The compounds were designed as topoisomerase I (Top1) inhibitors based on the indenoisoquinoline series of drugs. The results of biological evaluation demonstrate that, unlike very closely related dibenzo[c,h][1,6] naphthyridinediones, dibenzo[c,h][1,5]naphthyridinediones retain the Top1 inhibitory activity of similarly substituted indenoisoquinolines.