137813-35-5

Basic information

• Product Name: CYCLO(ARG-GLY-ASP-D-PHE-VAL)
• Synonyms: CYCLO(ARG-GLY-ASP-D-PHE-VAL);CYCLO(RGDD-FV);RGDFV PEPTIDE, CYCLIC;Cyclo(Arg-Gls-Asp-D-Phe-Val);EMD 66203, c(RGDfV);cRGDfV;EMD 66203
• CAS NO: 137813-35-5
• Molecular Formula: C26H38N8O7
• Molecular Weight: 574.63
• Mol File: 137813-35-5.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.45±0.1 g/cm3(Predicted)
• Storage Temp.: −20°C
• PKA: 4.01±0.10(Predicted)
• CAS DataBase Reference: CYCLO(ARG-GLY-ASP-D-PHE-VAL)(CAS DataBase Reference)
• NIST Chemistry Reference: CYCLO(ARG-GLY-ASP-D-PHE-VAL)(137813-35-5)
• EPA Substance Registry System: CYCLO(ARG-GLY-ASP-D-PHE-VAL)(137813-35-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 137813-35-5(Hazardous Substances Data)

Usage

General Description

Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation.

Biochem/physiol Actions

Primary Targetinhibits tumor cell adhesion to laminin and vitronectin substrates