137819-86-4

Basic information

• Product Name: 1 2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL
• Synonyms: 1 2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL;l-β,γ-dioleoyl-α-cephaline, 7-nitrobenzofurazan-labeled;Phosphatidylethanolamine 18:1, NBD-labeled, N-(7-Nitrobenzofurazan-4-yl)-1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, L-β,γ-Dioleoyl-α-cephaline, 7-nitrobenzofurazan-labeled
• CAS NO: 137819-86-4
• Molecular Formula: C47H79N4O11P
• Molecular Weight: 907.13
• Mol File: 137819-86-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 891.9°C at 760 mmHg
• Flash Point: 493.2°C
• Appearance: /
• Density: 1.115g/cm³
• Vapor Pressure: 3.7E-34mmHg at 25°C
• Refractive Index: 1.525
• Storage Temp.: −20°C
• PKA: 1.39±0.50(Predicted)
• CAS DataBase Reference: 1 2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1 2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL(137819-86-4)
• EPA Substance Registry System: 1 2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL(137819-86-4)

Safety Data

• WGK Germany: 3
• F: 10-21
• Hazardous Substances Data: 137819-86-4(Hazardous Substances Data)

Usage

Description

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) is a phospholipid that consists of two oleic acid chains and a glycerol phosphate head group. It plays a crucial role in the structure and function of cell membranes and is widely utilized in the formulation of liposomes and lipid nanoparticles for drug delivery purposes. DOPE's unique chemical structure contributes to the stability and fluidity of liposomal membranes, making it an essential component in the encapsulation and delivery of various therapeutic agents.

Uses

Used in Pharmaceutical Industry:
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is used as a key component in the formulation of liposomes and lipid nanoparticles for the encapsulation and delivery of drugs, genes, and other therapeutic molecules. Its ability to enhance the stability and fluidity of liposomal membranes makes it an effective tool for improving the efficiency of drug delivery.
Used in Drug Delivery Systems:
DOPE is used as a stabilizing agent in the development of targeted drug delivery systems. Its involvement in endocytosis and intracellular delivery of biomolecules allows for the efficient transport of therapeutic agents to specific cells and tissues, enhancing the overall effectiveness of treatment.
Used in Gene Therapy:
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine is used as a carrier molecule for the delivery of nucleic acids and proteins into cells, playing a significant role in the field of gene therapy. Its unique properties facilitate the successful introduction of therapeutic genes into target cells, potentially leading to the development of novel treatments for various genetic disorders.
Used in Vaccine Development:
DOPE is utilized in the formulation of vaccine adjuvants, which are substances that enhance the body's immune response to vaccines. Its ability to improve the delivery of antigens to immune cells contributes to the development of more effective vaccines.

InChI:InChI=1/C47H79N4O11P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-44(52)58-39-41(61-45(53)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)40-60-63(56,57)59-38-37-48-42-35-36-43(51(54)55)47-46(42)49-62-50-47/h17-20,35-36,41,48H,3-16,21-34,37-40H2,1-2H3,(H,56,57)/b19-17+,20-18+/t41-/m1/s1