1378372-37-2Relevant academic research and scientific papers
Total synthesis of (-)-galanthamine and (-)-lycoramine via catalytic asymmetric hydrogenation and intramolecular reductive Heck cyclization
Chen, Ji-Qiang,Xie, Jian-Hua,Bao, Deng-Hui,Liu, Sheng,Zhou, Qi-Lin
supporting information; experimental part, p. 2714 - 2717 (2012/08/08)
A synthetic strategy featuring efficient ruthenium-catalyzed asymmetric hydrogenation of racemic α-aryloxy cyclic ketone via dynamic kinetic resolution and palladium-catalyzed intramolecular reductive Heck cyclization has been developed for the asymmetric total synthesis of (-)-galanthamine (20.1%, 12 steps) and (-)-lycoramine (40.2%, 10 steps)
