137845-39-7

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 1262436-16-7 N-(1-(3,4-dimethoxyphenyl)-2-methylene-3-oxobutyl)-4-methylbenzenesulfonamide 
• 155880-43-6 3-Ethenyl-1-(benzenesulfonyl)-2-<(3,4-dimethoxyphenyl)methyl>indole 
• 916151-78-5 N-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-phenyl)-5-hydroxy-oct-7-enyl]-4-methyl-benzenesulfonamide 
• 916151-82-1 2-allyl-4-(tert-butyl-dimethyl-silanyloxy)-6-(3,4-dimethoxy-phenyl)-1-(toluene-4-sulfonyl)-piperidine 
• 1026097-20-0 N-[3-(tert-butyl-dimethyl-silanyloxy)-1-(3,4-dimethoxy-phenyl)-5-oxo-pentyl]-4-methyl-benzenesulfonamide 

Relevant academic research and scientific papers

Octahedron-based redox molecular sieves M-PKU-1 (M?=?Cr, Fe): A novel dual-centered solid acid catalyst for heterogeneously catalyzed Strecker reaction

Cr-PKU-1, an octahedron-based redox molecular sieve, was found to be an efficient, environmentally benign and easily recoverable catalyst for the heterogeneously-catalyzed Strecker reaction under the mild conditions. This material was evidenced to be a du

One-pot preparation of homopropargylic N-sulfonylamines catalyzed by zinc powder

A new one-pot method for synthesis of homopropargylic N-sulfonylamines from aldehydes catalyzed by zinc powder is described. The procedure is lauded by its simplicity, good yields, and adaptability to a wide variety of aldehydes.

Rh(III)-catalyzed olefination of N-sulfonyl imines: Synthesis of ortho -olefinated benzaldehydes

Rh(III)-catalyzed olefination of N-sulfonyl imines using acrylates and styrenes has been achieved for the synthesis of ortho-olefinated benaldehydes. This reaction proceeds via a chelation assisted C-H olefination/in situ hydrolysis process.

Preparation of N-arylsulfonyl imines from sulfonamides and aryl aldehydes using magnesium oxide as a heterogeneous and reusable catalyst under solvent-free conditions

An efficient solvent-free procedure for the preparation of N-arylsulfonyl imines from sulfonamides and aryl aldehydes in the presence of a catalytic amount of magnesium oxide and tetrabutylammonium bromide (TBAB) under microwave irradiation is described. The advantages of this method are good to high yields, short reaction times, low cost, and matching with green chemistry protocols. Copyright Taylor & Francis Group, LLC.

Practical and general entry to N-tosyl aryl aldimines promoted by sulfamic acid in water and alcohol

A practical, indirect procedure composed of a three-component condensation using aromatic aldehydes, p-tosylamide, and sodium p-toluenesulfinate in the presence of sulfamic acid in tap water-alcohol solvents to afford amidosulfones, and the subsequent wat

Small-molecule inhibitors of protein geranylgeranyltransferase type I

Small molecules that inhibit the geranylgeranylation of K-Ras4B and RhoA by protein geranylgeranyltransferase type I (GGTase-I) were identified from chemical genetic screens of heterocycles synthesized through phosphine catalysis of allenes. To further improve the efficacy of the GGTase-I inhibitors (GGTIs), 4288 related compounds bearing core dihydropyrrole/pyrrolidine and tetrahydropyridine/piperidine scaffolds were synthesized on SynPhase lanterns in a split-pool manner through phosphine-catalyzed [3 + 2] and [4 + 2] annulations of resin-bound allenoates. Testing of the 4288 analogues resulted in several GGTIs exhibiting submicromolar IC50 values. Because proteins such as Ras and Rho GTPases are implicated in oncogenesis and metastasis, these GGTIs might ultimately lead to the development of novel antitumor therapeutics. Copyright

A concise and enantioselective approach to the total synthesis of (-)-lasubine I

An efficient, enantioselective total synthesis of (-)-lasubine I (1) has been achieved in an overall 8.8% yield from readily available starting materials. The important features of this approach include the creation of stereogenic centers through two sequ

Asymmetric synthesis of β-amino acids through application of chiral sulfoxide

This paper describes asymmetric synthesis of β-aminophenylpropionic acid through application of a homochiral sulfoxide auxiliary. High kinetically controlled (3R,2S,RS)-diastereoselectivity (-60°C) is achieved during addition of the lithium enolate of tert-butyl (+)-(R)-p-toluenesulfinylacetate to substituted N-(benzylidene)toluene-4-sulfonamides 2a-2d. The reductive cleavage of adduct 3a with sodium amalgam yielded tert-butyl 3-(toluene-4-sulfonamido)-3-phenylpropionate 5a, which was subjected to ester hydrolysis and subsequent detosylation with sodium in liquid ammonia to yield (S)-β-aminophenylpropionic acid in good yield and high 91% e.e.

Solvent-free synthesis of N-sulfonylimines using microwave irradiation

N-Sulfonylimines are prepared expeditiously in a one-pot solventless operation by microwave thermolysis of aldehydes and sulfonamides in the presence of benign reagents, calcium carbonate and montmorillonite K 10 clay.