1378524-41-4

Basic information

• Product Name: VUF11207
• Synonyms: VUF11207;(E)-N-(3-(2-fluorophenyl)-2-Methylallyl)-3,4,5-triMethoxy-N-(2-(1-Methylpyrrolidin-2-yl)ethyl)benzaMide;(E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)benzamide trifluoroacetate salt;N-[(2E)-3-(2-Fluorophenyl)-2-methyl-2-propen-1-yl]-3,4,5-trimethoxy-N-[2-(1-methyl-2-pyrrolidinyl)ethyl]-benzamide trifluoroacetate salt;VUF11207 trifluoroacetate salt;VUF11207 Triflate;(E)-N-(3-(2-Fluorophenyl)-2-methylallyl)-3,4,5-trimethoxy-N-(2-(1-methylpyrrolidin-2-yl)ethyl)
• CAS NO: 1378524-41-4
• Molecular Formula: C₂₇H₃₅FN₂O₄
• Molecular Weight: 470.5762032
• EINECS: -0
• Mol File: 1378524-41-4.mol
• Article Data: 1

Chemical Properties

• Appearance: white to beige/
• Storage Temp.: ?20°C
• Solubility: H2O: soluble5mg/mL, clear (warmed)
• CAS DataBase Reference: VUF11207(CAS DataBase Reference)
• NIST Chemistry Reference: VUF11207(1378524-41-4)
• EPA Substance Registry System: VUF11207(1378524-41-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1378524-41-4(Hazardous Substances Data)

Usage

General Description

VUF11207 (N-(4-((4-methoxy-2,3,6,7-tetrahydro-1H-inden-1-yl)amino)-3-(trifluoromethyl)phenyl)acetamide) is a chemical compound that acts as a potent and selective antagonist of the metabotropic glutamate receptor subtype 1 (mGlu1). It has been studied for its potential use in the treatment of various neurological disorders, including Parkinson's disease, schizophrenia, and addiction. VUF11207 has shown promising effects in preclinical studies, including the ability to improve motor function and reduce dyskinesia in animal models of Parkinson's disease. Its selective antagonism of mGlu1 receptors make it a valuable tool for studying the role of these receptors in neurological function and for potential therapeutic development.

Upstream product

• 1375800-67-1 (E)-3-(2-fluorophenyl)-2-methyl-N-(2-(1-methylpyrrolidin-2-yl)ethyl)prop-2-en-1-amine 
• 4521-61-3 3,4,5-Trimethoxybenzoyl chloride 
• 1375800-37-5 (E)-3-(2-fluorophenyl)-2-methylacrylaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 51387-90-7 2-(2-AMINOETHYL)-1-METHYLPYRROLIDINE 
• 118-41-2 Eudesmic acid 

Relevant articles and documents

Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists

The chemokine receptor CXCR7 is an atypical G protein-coupled receptor as it preferentially signals through the β-arrestin pathway rather than through G proteins. CXCR7 is thought to be of importance in cancer and the development of CXCR7-targeting ligands is of huge importance to further elucidate the pharmacology and the therapeutic potential of CXCR7. In the present study, we synthesized 24 derivatives based on a compound scaffold patented by Chemocentryx and obtained CXCR7 ligands with pKi values ranging from 5.3 to 8.1. SAR studies were supported by computational 3D Fingerprint studies, revealing several important affinity descriptors. Two key compounds (29 and 30, VUF11207 and VUF11403) were found to be high-potency ligands that induce recruitment of β-arrestin2 and subsequent internalization of CXCR7, making them important tool compounds in future CXCR7 research.