137863-20-8

Basic information

• Product Name: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester
• Synonyms: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester;(S)-benzyl2-(N-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)pentanamido)-3-methylbutanoate;Valsartan Benzyl Ester;L-Valine, N-(1-oxopentyl)-N-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]- 4-yl]methyl]-, phenylmethyl ester;(S)-N-Valeryl-N-([2'-(1-H-tetrazole-5-yl)biphenyl-4-yl]-Methyl)valine benzyl ester;Valsartan Related CoMpound C;(S)-N-Valeryl-N-([2'-(1H-tetrazole-5-yl)biphen-4-yl]methyl)valine benzyl ester;Valsartan Related Compound C (10 mg) ((S)-N-Valeryl-N-([2'-(1-H-tetrazole-5-yl)biphenyl-4-yl]-methyl)valine benzyl ester)
• CAS NO: 137863-20-8
• Molecular Formula: C₃₁H₃₅N₅O₃
• Molecular Weight: 525.649
• Product Categories: Amino Acids & Derivatives;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 137863-20-8.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 720.1 °C at 760 mmHg
• Flash Point: 389.3 °C
• Appearance: /
• Density: 1.18 g/cm³
• Vapor Pressure: 0-0Pa at 20-25℃
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 4.15±0.10(Predicted)
• CAS DataBase Reference: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester(137863-20-8)
• EPA Substance Registry System: N-[2’-(1H-tetrazol-5-yl)biphenyl-4-yl methyl]-N-Valeryl-(L)-Valine benzyl ester(137863-20-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 137863-20-8(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 137863-20-8 differently. You can refer to the following data:
1. Valsartan (V095750) intermediate.
2. Valsartan (V095750) intermediate. Valsartan USP Related Compound C.

Upstream product

• 676129-93-4 (S)-3-methyl-2-((2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl)-amino)-butyric acid benzyl ester 
• 638-29-9 n-valeryl chloride 
• 137864-22-3 (S)-2-[(2'-cyanobiphenyl-4-ylmethyl)pentanoylamino]-3-methylbutyric acid benzyl ester 
• 67-56-1 methanol 
• 137864-44-9 N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeroyl-(L)-valine benzyl ester 
• 114772-53-1 2-Cyano-4'-methylbiphenyl 
• 2042-37-7 o-cyanobromobenzene 
• 114772-54-2 4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile 
• 137864-24-5 (S)-2-[(2'-cyanobiphenyl-4-ylmethyl)amino]-3-methylbutyric acid benzyl ester hydrochloride 
• 124750-51-2 N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole 
• 2462-34-2 L-valine benzyl ester hydrochloride 
• 151052-40-3 2'-(1H-tetrazol-5-yl)biphenyl-4-carbaldehyde 
• 133292-05-4 4-(diethoxymethyl)phenylmagnesium bromide 
• 16652-76-9 L-valine benzyl ester p-toluenesulfonate salt 

Downstream Products

• 137862-53-4 N-pentanoyl-N-[[2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]-methyl]-(L)-valine 

Relevant articles and documents

Synthesis of 5-Substituted 1 H-Tetrazoles from Nitriles by Continuous Flow: Application to the Synthesis of Valsartan

An efficient continuous flow process for the synthesis of 5-substituted 1H-tetrazoles is described. The process involves the reaction between a polymer-supported triorganotin azide and organic nitriles. The polymer-supported organotin azide, which is in situ generated with a polystyrene-supported triorganotin alkoxide and trimethylsilylazide, is immobilized in a packed bed reactor. This approach is simple, fast (it takes from 7.5 to 15 min), and guarantees a low concentration of tin residues in the products (5 ppm). The process was developed to aryl-, heteroaryl-, and also alkylnitriles and was applied for the synthesis of valsartan, an angiotensin II receptor antagonist.

PROCESS FOR PREPARATION OF 5-SUBSTITUTED TETRAZOLES

The present invention is a process for preparing sterically hindered 5-substituted tetrazole, which comprises of reacting a nitrile with an organotin halide and an azide in presence of a phase transfer catalyst, in an organic solvent and a co- solvent at reflux temperature for 4 to 20 h.

PROCESSES FOR THE PREPARATION OF INTERMEDIATES OF VALSARTAN

The present invention relates to processes for the preparation of intermediates of valsartan.