137885-35-9Relevant academic research and scientific papers
Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors
Gundersen, Eric,Fan, Kristi,Haas, Kimberly,Huryn, Donna,Jacobsen, J. Steven,Kreft, Anthony,Martone, Robert,Mayer, Scott,Sonnenberg-Reines, June,Sun, Shaiu-Ching,Zhou, Hua
, p. 1891 - 1894 (2007/10/03)
Alzheimer's disease (AD) is a debilitating disease widely thought to be associated with the accumulation of beta amyloid (Aβ) in the brain. Inhibition of γ-secretase, one of the enzymes responsible for Aβ production, may be a useful strategy for the treatment of AD. Described below is a series of γ-secretase inhibitors designed from a scaffold identified by a ROCS [J. Comput. Chem. 1996, 17, 1653] search of the corporate database.
