1378861-92-7Relevant articles and documents
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Corbett,Dirico,Song,Boscoe,Doran,Boyer,Qiu,Ammirati,VanVolkenburg,McPherson,Parker,Cox
, p. 6707 - 6713 (2008/09/17)
The cis-3-amino-4-(2-cyanopyrrolidide)-pyrrolidine template has been shown to afford low nanomolar inhibitors of human DPP-IV that exhibit a robust PK/PD profile. An X-ray co-crystal structure of 5 confirmed the proposed mode of binding. The potent single
