1378869-35-2

Usage

Functional groups

Bromine (Br), trifluoromethoxy (CF3O), and bromomethyl (CH2Br)

Structure

Aromatic benzene ring with a bromine atom at the 1st position, a trifluoromethoxy group at the 2nd position, and a bromomethyl group at the 4th position

Type of compound

Brominated aromatic compound

Applications

a. Organic synthesis
b. Pharmaceutical research
c. Building block for the synthesis of various organic compounds
d. Development of new drugs and biologically active molecules
e. Potential applications in materials science and agrochemical industries

Safety precautions

Handle and use with proper safety measures and in accordance with relevant regulations.

Upstream product

• 1011531-67-1 (4-bromo-3-(trifluoromethoxy)phenyl)methanol 
• 175278-22-5 4-amino-3-(trifluoromethoxy)benzoic acid 
• 457097-93-7 4-amino-3-trifluoromethoxybenzoic acid methyl ester 
• 957206-36-9 4-bromo-3-trifluoromethoxy-benzoic acid methyl ester 

Downstream Products

• 1011531-68-2 (S)-3-((S)-3-(4-(4-bromo-3-(trifluoromethoxy)benzyloxy)-phenyl)-3-(isoxazol-3-yl)propanoyl)-4-benzyloxazolidin-2-one 
• 1378868-59-7 N-(4-bromo-3-(trifluoromethoxy)benzyl)-N-(4-cyclopropylpyridin-3-yl)methanesulfonamide 
• 1378868-32-6 (4-((N-(5-cyclopropyl-2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-a]pyridin-6-yl)methylsulfonamido)methyl)-2-(trifluoromethoxy)phenyl)boronic acid 
• 1378868-65-5 5-cyclopropyl-2-(4-fluorophenyl)-N-methyl-6-(N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)benzyl)methylsulfonamido)pyrazolo[1,5-a]pyridine-3-carboxamide 
• 1378868-63-3 6-(N-(4-bromo-3-(trifluoromethoxy)benzyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylic acid 
• 1378868-62-2 ethyl 6-(N-(4-bromo-3-(trifluoromethoxy)benzyl)methylsulfonamido)-5-cyclopropyl-2-(4-fluorophenyl)pyrazolo[1,5-a]pyridine-3-carboxylate 
• 1378868-60-0 1-amino-3-(N-(4-bromo-3-(trifluoromethoxy)benzyl)methylsulfonamido)-4-cyclopropylpyridinium 

Relevant academic research and scientific papers

SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

HETEROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula I: where the definitions of the variables are provided herein. The present invention also provides compositions that include, and methods for using, the compounds in preparing medicaments and for treating metabolic disorders such as, for example, type II diabetes.