1378941-83-3Relevant academic research and scientific papers
Cooperative dienamine/hydrogen-bonding catalysis: Enantioselective formal [2+2] cycloaddition of enals with nitroalkenes
Talavera, Garazi,Reyes, Efraím,Vicario, Jose L.,Carrillo, Luisa
, p. 4104 - 4107 (2012/06/04)
Two can play this game: The title reaction is catalyzed by a chiral secondary amine in the presence of an achiral thiourea for the enantio- and diastereoselective synthesis of highly functionalized cyclobutanes (see scheme; TMS=trimethylsilyl). Mechanistically, two consecutive Michael reactions proceed through an unprecedented combination of an dienamine/iminium activation mode. Copyright
