13791-03-2

Basic information

• Product Name: 1-FLUORO-7-METHOXYNAPHTHALENE
• Synonyms: 1-FLUORO-7-METHOXYNAPHTHALENE;Naphthalene, 1-fluoro-7-Methoxy-
• CAS NO: 13791-03-2
• Molecular Formula: C₁₁H₉FO
• Molecular Weight: 176.1869632
• Mol File: 13791-03-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 272.303°C at 760 mmHg
• Flash Point: 102.473°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 0.01mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-FLUORO-7-METHOXYNAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FLUORO-7-METHOXYNAPHTHALENE(13791-03-2)
• EPA Substance Registry System: 1-FLUORO-7-METHOXYNAPHTHALENE(13791-03-2)

Safety Data

• Hazardous Substances Data: 13791-03-2(Hazardous Substances Data)

Usage

General Description

1-Fluoro-7-methoxynaphthalene is a chemical compound that belongs to the class of fluorinated naphthalene derivatives. It is commonly used in the production of various pharmaceuticals, agrochemicals, and organic compounds. 1-FLUORO-7-METHOXYNAPHTHALENE is known for its high reactivity and is frequently employed as an intermediate in the synthesis of more complex chemicals. Its unique properties make it a valuable building block in organic chemistry, especially in the field of medicinal chemistry and drug development. However, it is important to handle this compound with care, as it is toxic and may cause irritation to the skin, eyes, and respiratory system if mishandled. Overall, 1-fluoro-7-methoxynaphthalene is a versatile and important chemical in the manufacturing of various compounds and pharmaceuticals.

InChI:InChI=1/C11H9FO/c1-13-9-6-5-8-3-2-4-11(12)10(8)7-9/h2-7H,1H3

Upstream product

• 71493-51-1 1-amino-7-methoxynaphthalene hydrochloride 
• 6470-18-4 1-acetylamino-7-naphthol 
• 13916-98-8 1-fluoro-7-hydroxynaphthalene 
• 77-78-1 dimethyl sulfate 
• 5302-79-4 7-methoxynaphthalen-1-amine 
• 93189-18-5 N-(7-methoxynaphthalen-1-yl)acetamide 
• 118-46-7 8-amino-2-naphthol 

Downstream Products

• 627526-70-9 8-fluoro-naphthalene-2-boronic acid 
• 82995-08-2 2-<2-<1-(4-fluoro-6-methoxynaphthyl)-1-hydroxyethyl>phenyl>-4,4-dimethyl-2-oxazoline 
• 82995-10-6 2-<1-(4-fluoro-6-methoxynaphthyl)ethyl>benzoic acid 
• 82995-06-0 3-bromo-1-fluoro-7-hydroxynaphthalene 
• 550998-43-1 1-chloro-8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol 
• 550998-33-9 8-fluoro-6-(3-fluoro-4-methoxyphenyl)-2-naphthol 
• 550998-44-2 1-chloro-8-fluoro-6-(4-methoxyphenyl)-2-naphthol 
• 550998-32-8 8-fluoro-6-(4-methoxyphenyl)-2-naphthol 
• 13916-98-8 1-fluoro-7-hydroxynaphthalene 

Relevant articles and documents

Novel 3-oxazolidinedione-6-aryl-pyridinones as potent, selective, and orally active EP3 receptor antagonists

High-throughput screening and subsequent optimization led to the discovery of novel 3-oxazolidinedione-6-aryl-pyridinones exemplified by compound 2 as potent and selective EP3 antagonists with excellent pharmacokinetic properties. Compound 2 was orally active and showed robust in vivo activities in overactive bladder models. To address potential bioactivation liabilities of compound 2, further optimization resulted in compounds 9 and 10, which maintained excellent potency, selectivity, and pharmacokinetic properties and showed no bioactivation liability in glutathione trapping studies. These highly potent, selective, and orally active EP3 antagonists are excellent tool compounds for investigating and validating potential therapeutic benefits from selectively inhibiting the EP3 receptor.

Substituted phenyl naphthalenes as estrogenic agents

This invention provides estrogen receptor modulators of formula I, having the structure 1wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10, are as defined in the specification, or a pharmaceutically acceptable salt thereof.

Fluoronaphthylones

4-(6-Substituted naphthyl)butan-2-ols,-butan-2-ones,-pentan-2-ols and -pentan-2-ones bearing a fluoro group in the naphthyl ring, and pro-drugs thereof, are anti-inflammatory agents. A typical embodiment is 4-(4-fluoro-6-methoxy-2-naphthyl)-butan-2-one.