137918-81-1

Basic information

• Product Name: Piperazine, 1,4-bis[2-nitro-4-(trifluoromethyl)phenyl]-
• CAS NO: 137918-81-1
• Molecular Formula: C18H14F6N4O4
• Molecular Weight: 464.324
• Mol File: 137918-81-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Piperazine, 1,4-bis[2-nitro-4-(trifluoromethyl)phenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1,4-bis[2-nitro-4-(trifluoromethyl)phenyl]-(137918-81-1)
• EPA Substance Registry System: Piperazine, 1,4-bis[2-nitro-4-(trifluoromethyl)phenyl]-(137918-81-1)

Safety Data

• Hazardous Substances Data: 137918-81-1(Hazardous Substances Data)

Upstream product

• 110-85-0 piperazine 
• 367-86-2 1-fluoro-2-nitro-4-trifluoromethyl-benzene 
• 121-17-5 2-chloro-3-nitro-5-trifluoromethylbenzene 

Relevant articles and documents

Nucleophilic aromatic substitution reactions under aqueous, mild conditions using polymeric additive HPMC

The use of the inexpensive, benign, and sustainable polymer, hydroxypropyl methylcellulose (HPMC), in water enables nucleophilic aromatic subsitution (SNAr) reactions between various nucleophiles and electrophiles. The mild reaction conditions facilitate a broad functional group tolerance that can be utilized for subsequent derivatization for the synthesis of pharmaceutically relevant building blocks. The use of only equimolar amounts of all reagents and water as reaction solvent reveals the greenness and sustainability of the methodology presented herein.