137929-90-9Relevant academic research and scientific papers
SYNTHESIS, AND REACTIONS OF SOME NEW PYRAZOLINES FROM CHALCONES AND THE SCREENING OF THEIR ANTIBACTERIAL ACTIVITIES
El-Hashash, M. A.,Soliman, F. M. A.,Souka, L. M.,Salman, A. S. S.
, p. 59 - 66 (2007/10/03)
Condensation of 4-methyl-2-methoxy-, 3,4-dimethyl- and/or 4-methyl-2-chloroacetophenone with p-chloro- and/or p-nitrobenzaldehyde gave the corresponding chalcones 1a-e.Condensation of 1 with hydrazine hydrate, phenylhydrazine, and/or semicarbazide gave the corresponding pyrazolines 2,9, and 10.Addition of formic, acetic and propionic acids to 2 yielded the corresponding derivatives 3,4 and 5.Addition of benzoyl chloride, benzenesulphonyl chloride and/or bromine to 2 yielded the corresponding derivatives 6,7 and 8.The antibacterial tests against Gram-positive, and Gram-negative bacteria, yeast, and fungi are also screened.
