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1379307-48-8

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1379307-48-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1379307-48-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,7,9,3,0 and 7 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1379307-48:
(9*1)+(8*3)+(7*7)+(6*9)+(5*3)+(4*0)+(3*7)+(2*4)+(1*8)=188
188 % 10 = 8
So 1379307-48-8 is a valid CAS Registry Number.

1379307-48-8Downstream Products

1379307-48-8Relevant articles and documents

Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria

Abas, Siti Nurdiana,Aguiar, Anna Caroline Campos,Ang, Xiaoman,Blaquiere, Nicole,Bodenreider, Christophe,Campbell, Simon,Campo, Brice,Chan, Katherine,Chan, Wai Ling,Chen, Yen-Liang,Cooper, Roland A.,Crespo-Fernandez, Benigno,Diagana, Thierry T.,Ding, Mei,Fang, Eric,Gamo, Francisco Javier,Guiguemde, Armand,Huang, Richard,Jain, Jay Prakash,Kirrane, Tom,Lakshminarayana, Suresh B.,Lanshoeft, Christian,Lim, Jessie,Liu, Yugang,Mata, Anne-Catherine,Pei, Luying,Qumber, Jafri,Rosenthal, Philip J.,Sarko, Christopher,Schulz, Hanna,Shu, Wei,Sim, Sandra,Simon, Oliver,Straimer, Judith,Taft, Benjamin R.,Thompson, Christopher,Tumwebaze, Patrick,Vankadara, Subramanyam,Waldron, Grace,Yokokawa, Fumiaki,Zou, Bin,Angulo-Barturen, I?igo,Jiménez-Díaz, María Belén,Wagner, Jürgen

supporting information, p. 3798 - 3813 (2022/03/16)

A series of 5-aryl-2-amino-imidazothiadiazole (ITD) derivatives were identified by a phenotype-based high-throughput screening using a blood stage Plasmodium falciparum (Pf) growth inhibition assay. A lead optimization program focused on improving antiplasmodium potency, selectivity against human kinases, and absorption, distribution, metabolism, excretion, and toxicity properties and extended pharmacological profiles culminated in the identification of INE963 (1), which demonstrates potent cellular activity against Pf 3D7 (EC50 = 0.006 μM) and achieves “artemisinin-like” kill kinetics in vitro with a parasite clearance time of 1/2) across species. These properties suggest the significant potential for INE963 (1) to provide a curative therapy for uncomplicated malaria with short dosing regimens. For these reasons, INE963 (1) was progressed through GLP toxicology studies and is now undergoing Ph1 clinical trials.

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