137934-89-5Relevant academic research and scientific papers
Formation of isoxazolines N-oxides and dihydrofurans from a cyclocondensation between bromo or chloromalonate carbanion and Michael acceptors
Menn, J. C. Le,Sarrazin, J.,Tallec, A.
, p. 562 - 565 (2007/10/02)
Heterocyclic compounds are prepared by a cyclocondensation reaction between halomalonate carbanion and Michael acceptors : α-nitroalkenes lead to isoxazolines N-oxides and α,β-unsaturated carbonyl derivatives to dihydrofurans.Formation of the carbanion results from deprotonation of monohalomalonates with powdered potassium carbonate in THF; as a rule; chloromalonate affords better yields than bromomalonate.Key Words: halomalonate carbanions / electrophilic alkenes / dihydrofurans / isoxazolines N-oxide
