137935-98-9Relevant academic research and scientific papers
Simple Preparation of (2,2'-Biphenylylene)phenylphosphine Oxide and Role of Triphenylphosphine Oxide as a Mediator for Formation of Biaryl Derivatives
Ogawa, Satoshi,Tajiri, Yoko,Furukawa, Naomichi
, p. 3182 - 3184 (2007/10/02)
(2,2'-Biphenylylene)phenylphosphine oxide (3) was prepared simply by the reaction of triphenylphosphine oxide (1) with phenyllithium and subsequently with aqueous hydrogen peroxide in acetic acid.The oxide 3 reacted with lithium diisopropylamide (LDA) and then with several elctrophiles to afford regiospecifically ortho-substituted compounds in moderate yields, which were converted to unsymmetrical 2- and 2,3'-substituted 1,1'-biaryls and triphenylphosphine oxide (1).
