137937-39-4

Usage

Preparation

Obtained (by-product) by Fries rearrangement of m-tolyl phenylacetate with aluminium chloride in chlorobenzene at 140° for 4 h (5%).

Upstream product

• 122-27-0 3-methylphenyl phenylacetate 
• 1030446-72-0 2-methoxy-6-methylbenzaldehyde oxime 
• 1408089-50-8 1-(2-methoxy-6-methylphenyl)-2-phenylethanone 
• 53005-44-0 2-methoxy-6-methyl-benzonitrile 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 2491-29-4 2-methylphenyl phenylacetate 

Downstream Products

• 1408089-52-0 2-(1-(benzyloxy)ethyl)-5-methyl-3-phenyl-4H-chromen-4-one 
• 1408089-54-2 2-(1-hydroxyethyl)-5-methyl-3-phenyl-4H-chromen-4-one 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES

The present invention provides PI3K protein kinase modulators, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of kinase mediated diseases or disorders with them.

Selectivity in the photo-Fries reaction of phenyl phenylacetates included in a nation membrane

Photoirradiation of phenyl phenylacetates included within a Nafion membrane exclusively resulted in ortho-hydroxyphenones, thus achieving high selectivity in the photo-Fries reaction.

Photochemistry of phenyl phenylacetates adsorbed on pentasil and faujasite zeolites

The photochemistry of phenyl phenylacetate 1, p-tolyl phenylacetate 2, o-tolyl phenylacetate 3 and phenyl o-tolylacetate 4 was investigated both in homogeneous solution and adsorbed on ZSM-5 and NaY zeolites.Photolyses of these esters in acetonitrile result in photo-Fries rearrangement products, phenols and diphenylethane as well as phenyl benzyl ethers.In contrast, photolyses of these esters adsorbed on NaY zeolite only give the ortho Fries rearrangemnt products.On the other hand, the photochemical reaction of 1 and 2 adsorbed on ZSM-5 zeolite only produces toluene and phenols, while under identical conditions the photochemical products for 3 and 4 are the Fries rearrangement and decarbonylation products. the product distributions for these esters adsorbed both on ZSM-5 and NaY zeolites are different from those for dibenzyl ketones as reported in the literature.All of these observations are interpreted in terms of (a) the size and shape sorption selectivity of ZSM-5 zeolite, (b) restriction of duffusional and rotational mobility of the radical pair imposed by the zeolite surface and (c) the multiplicity of the excited state responsible for the homolytic bond cleavage.

A REEXAMINATION OF THE RETRO-FRIES REARRANGEMENT OF SOME o-HYDROXYKETONES

The retro-Fries rearrangement, catalyzed by protic and Lewis acids, was studied for some o-hydroxyketones.The results are consistent with the mechanism of an heterolytic cleavage and rearrangement.It appears that, in general, Lewis acids do not induce the retro-Fries rearrangement of o-hydroxyketones.However, in certain cases, it may be brought about the presence of a protic acid generated in situ, from a solvent-catalyst interaction.