1379453-70-9

Basic information

• Product Name: 2-ethylthio-N₆-(4-methylbenzyl)adenosine
• Synonyms: 2-ethylthio-N₆-(4-methylbenzyl)adenosine
• CAS NO: 1379453-70-9
• Molecular Weight: 431.516
• Mol File: 1379453-70-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-ethylthio-N₆-(4-methylbenzyl)adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethylthio-N₆-(4-methylbenzyl)adenosine(1379453-70-9)
• EPA Substance Registry System: 2-ethylthio-N₆-(4-methylbenzyl)adenosine(1379453-70-9)

Safety Data

• Hazardous Substances Data: 1379453-70-9(Hazardous Substances Data)

Upstream product

• 221552-84-7 6-chloro-2-ethylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine 
• 6979-94-8 2',3',5'-tri-O-acetyl-guanosine 
• 118-00-3 G 
• 16321-99-6 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 

Relevant articles and documents

Synthesis of N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines as antiplatelet agents

A series of novel N6-alkyl(aryl)-2-alkyl(aryl)thioadenosines were synthesized, and their human antiplatelet aggregation activities were evaluated by the stimulation of adenosine 5′-diphosphate (ADP). Some of these compounds showed strong activity, among which compound 5b11 displayed the highest activity with an IC50 value of 29 ± 3 μM. Furthermore, five compounds were tested against arachidonic acid (AA)-induced human platelet aggregation. The results showed that compound 5b10 exhibited the highest activity with an IC50 value of 3 ± 2 μM. The adenosine derivatives substituted with a phenethyl group at the N6 position and a methylthio or ethylthio group at the C-2 position displayed high antiplatelet aggregation activity.