1379470-72-0

Upstream product

• 52516-81-1 (Z)-1-Chlor-1,4-diphenylbut-1-en-3-in 
• 5720-05-8 4-methylphenylboronic acid 
• 932-88-7 1-iodo-2-phenylethyne 
• 932-87-6 1-Bromo-2-phenylacetylene 
• 19676-33-6 (Z)-(2-bromo-1-chlorovinyl)benzene 

Relevant academic research and scientific papers

Hydrogen-Bonding-Assisted Br?nsted Acid and Gold Catalysis: Access to Both (E)- and (Z)-1,2-Haloalkenes via Hydrochlorination of Haloalkynes

We have developed an efficient synthesis of both (Z)- and (E)-chlorohaloalkenes via hydrochlorination of haloalkynes, based on two distinct hydrogen-bond-network-assisted catalytic systems: Br?nsted acid catalysis and gold catalysis. Both systems offer high stereoselectivity, good chemical yields, and diverse functional group tolerance.

Highly stereoselective synthesis of (Z)-1,2-dihaloalkenes by a Pd-catalyzed hydrohalogenation of alkynyl halides

An unprecedented Pd-catalyzed hydrohalogenation of alkynyl halides for the regio- and stereoselective synthesis of (Z)-1,2-dihaloalkenes has been realized using [(allyl)PdCl]2 as the catalyst and cis,cis-1,5-cyclooctadiene as the ligand. The advantages of this protocol are well illustrated by the assembly of trisubstituted (Z)-enynes and multifunctional benzenes via iterative cross-coupling reactions or tandem Diels-Alder-aromatization reactions, respectively.