1379474-61-9Relevant academic research and scientific papers
Synthesis, σ1, σ2-receptors binding affinity and antiproliferative action of new C1-substituted adamantanes
Riganas, Stefanos,Papanastasiou, Ioannis,Foscolos, George B.,Tsotinis, Andrew,Bourguignon, Jean-Jacques,Serin, Guillaume,Mirjolet, Jean-Fran?ois,Dimas, Kostas,Kourafalos, Vassilios N.,Eleutheriades, Andreas,Moutsos, Vassilios I.,Khan, Humaira,Georgakopoulou, Stavroula,Zaniou, Angeliki,Prassa, Margarita,Theodoropoulou, Maria,Pondiki, Stavroula,Vamvakides, Alexandre
experimental part, p. 3323 - 3331 (2012/07/28)
The synthesis of N-{4-[a-(1-adamantyl)benzyl]phenyl}piperazines 2a-e is described. The in vitro antiproliferative activity of most compounds against main cancer cell lines is significant. The σ1, σ2-receptors and sodium channels binding affinity of compounds 2 were investigated. One of the most active analogs, 2a, had an interesting in vivo anticancer profile against the BxPC-3 and Mia-Paca-2 pancreas cancer cell lines with caspase-3 activation, which was associated with an anagelsic activity against the neuropathic pain.
