13795-41-0Relevant academic research and scientific papers
A potential greener protocol for peptide coupling reactions using recyclable/reusable ionic liquid [ C 4-DABCO ] [ N(CN) 2 ]
Konwar, Manashjyoti,Khupse, Nageshwar D,Saikia, Prakash J,Sarma, Diganta
, (2018/05/15)
Abstract : Development of greener methodologies in synthetic organic chemistry has brought awareness in recent decades due to the ecological performance of green solvent media and catalytic systems. Here, we carried out the peptide bond formation reaction in one of the environmentally secure solvents, ‘ionic liquids’ in the presence of coupling reagent and in the absence of external base at room temperature, affording dipeptides in good to excellent yields. GRAPHICAL ABSTRACT: SYNOPSIS We carried out the peptide bond formation reaction in ionic liquids in the presence of a coupling reagent at room temperature, in the absence of an external base, affording dipeptides in good to excellent yields.
Asymmetric Induction during the Aminolysis of 5(4H)-Oxazolones from N-Benzoyl Amino Acids; Almost Specific Formation of One Epimer in the Reaction of the Oxazolone from N-Benzoyl-DL-t-leucine with Methyl L-Prolinate
Miyazawa, Toshifumi,Otomatsu, Toshihiko,Higashi, Katsutoshi,Yamada, Takashi,Kuwata, Shigeru
, p. 4161 - 4163 (2007/10/02)
Asymmetric induction during the aminolysis of 5(4H)-oxazolones from N-benzoyl amino acids was investigated using a series of amino acid esters as amine nucleophiles.The reaction of the oxazolone from N-benzoyl-DL-t-leucine with methyl L-prolinate was found to produce the diastereomeric D-L isomer, almost specifically, under appropriate conditions.
ASYMMETRIC HYDROGENATION OF DEHYDROVALYL PEPTIDES
Calderon, S.,Cativiela, C.,Mayoral, J. A.,Melendez, E.
, p. 435 - 438 (2007/10/02)
Both N-benzoyl-Δ-valyl-L and D-phenylalanine methyl esters were hydrogenated at atmospheric pressure in quantitative yield, using 5percent Pd/C suspended in n-propanol.Diastereoselectivity is low but in line of expectations.
Chiral Environments for Asymmetric Hydrogenation of Model Didehydro-Amino Acid Residues
Davies, John S.,Eaton, Mark C.,Ibrahim, M. Nazar
, p. 1813 - 1814 (2007/10/02)
Nmr and glc analysis of diastereoisomeric mixtures of dipeptides has been used to study the asymmetric hydrogenation of model benzoyldidehydro- and trifluoroacetyldidehydro-dipeptide methyl esters.Chiral enhancement of one isomeric form appears to be inde
