1379511-83-7Relevant academic research and scientific papers
PROCESSES FOR PREPARING INDOLES
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Paragraph 00165, (2013/07/05)
Methods for the synthesis of an indole in provided. Methods comprise oxidizing a N-aryl imine in the presence of a palladium-based catalyst, an oxidant, and a solvent.
Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: Indole synthesis from anilines and ketones
Wei, Ye,Deb, Indubhusan,Yoshikai, Naohiko
supporting information; experimental part, p. 9098 - 9101 (2012/07/14)
We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.
