1379513-68-4

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 142121-93-5 2-((tert-butoxycarbonyl)amino)-2-(4-fluorophenyl)acetic acid 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 7292-73-1 (2RS)-N-(p-fluorophenyl)glycine 

Downstream Products

• 1379513-69-5 (3R)-3-(2-(tert-butoxycarbonylamino)-2-(4-fluorophenyl)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1379514-05-2 (3R)-3-(2-(4-fluorophenyl)-2-(phenylsulfonamido)acetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane 2,2,2-trifluoroacetate 
• 1379514-03-0 (R)-quinuclidin-3-yl 2-(4-fluorophenyl)-2-(phenylsulfonamido)acetate 

Relevant academic research and scientific papers

HETEROARYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to novel compounds of formula (I) which are both phosphodiesterase 4 (PDE4) enzyme inhibitors and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

The invention relates to novel compounds which are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.

NOVEL COMPOUNDS

Compounds of formula (I) defined herein are both inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists and are useful for the prevention and/or treatment of a disease of the respiratory tract characterized by airway obstruction.

GLYCINE DERIVATIVES AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS

The present invention relates to alkaloid aminoester derivatives acting as muscarinic receptor antagonists, processes for their preparation, compositions comprising them and therapeutic uses thereof.

GLYCINE DERIVATIVES AND MEDICINAL COMPOSITIONS THEREOF

Alkaloid aminoester derivatives according to formula (I) and (VI) act as muscarinic receptor antagonists.