1379520-45-2Relevant academic research and scientific papers
Conformational properties of O-alkylated benzamides
Prabhakaran, Panchami,Azzarito, Valeria,Jacobs, Tia,Hardie, Michaele J.,Kilner, Colin A.,Edwards, Thomas A.,Warriner, Stuart L.,Wilson, Andrew J.
, p. 4485 - 4491 (2012/07/27)
In this article, we report the synthesis, solid-state and solution-state conformational studies of O-alkylated aromatic benzamides based on two scaffolds. Intramolecular hydrogen bonding provides conformational pre-organization and side chains can interact with each other within a molecule. In the solid-state three-dimensional arrangement, the molecules further interact with each other through non-covalent interactions. Given, the demonstrated potential of this class of scaffolds to act as helix mimetics for the inhibition of protein-protein interactions (PPIs), these results provide key insight for future inhibitor design.
2-O-Alkylated para-benzamide α-helix mimetics: The role of scaffold curvature
Azzarito, Valeria,Prabhakaran, Panchami,Bartlett, Alice I.,Murphy, Natasha S.,Hardie, Michaele J.,Kilner, Colin A.,Edwards, Thomas A.,Warriner, Stuart L.,Wilson, Andrew J.
, p. 6469 - 6472 (2012/09/08)
The design and synthesis of a new 2-O-alklyated benzamide α-helix mimetic is described. Comparison with regioisomeric 3-O-alkylated benzamides permits a preliminary evaluation of the role that mimetic curvature has in determining molecular recognition properties.
