1379524-31-8Relevant articles and documents
Developing diazirine-based chemical probes to identify histone modification 'readers' and 'erasers'
Yang, Tangpo,Liu, Zheng,Li, Xiang David
, p. 1011 - 1017 (2015)
Post translational modifications (PTMs, e.g., phosphorylation, acetylation and methylation) of histone play important roles in regulating many fundamental cellular processes such as gene transcription, DNA replication and damage repair. While 'writer' and
Enantiopure synthesis of side chain-modified α-amino acids and 5-cis-alkylprolines
Mohite, Amar R.,Bhat, Ramakrishna G.
, p. 5423 - 5428 (2012/08/28)
A short, concise synthesis of enantiopure, side chain-modified α-amino acids such as 4-oxo-l-norvaline, 6-oxo-l-homonorleucine, and 5-cis-alkyl prolines is described. Knoevenagel condensation of l-aminocarboxylate-derived β-ketoesters with aldehydes followed by reductive decarboxylation results in unnatural α-amino acids in good yield. A fluorescent amino acid is synthesized using a similar protocol. These studies show that aminocarboxylate-derived β-ketoesters are very useful intermediates and the method employed is both general and practical for the preparation of γ(δ)-oxo α-amino acids and alkylprolines.
